| Yeast Studies Offer Clues To Controlling Cholesterol Rise |
| Having discovered how a lowly, single-celled fungus regulates its version of cholesterol, Johns Hopkins researchers are gaining new insight about the target and action of cholesterol-lowering drugs taken daily by millions of people to stave off heart attacks and strokes. Their work appears in the December issue of Cell Metabolism. In humans, statin drugs inhibit an enzyme, HMG-CoA reductase, to lower blood cholesterol.
12/03/2008
|
| Researchers Learn That Some 'Good Cholesterol' Isn't Good Enough |
| If you think your levels of "good cholesterol" are good enough, a new study published in the December 2008 issue of The FASEB Journal suggests that you may want to think again. In the report, researchers from the University of Chicago challenge the conventional wisdom that simply having high levels of good cholesterol (HDL) and low levels of bad cholesterol (LDL) is necessary for good heath.
12/01/2008
|
| Dramatic JUPITER Findings Fail To Sway Prescribing Behavior, Poll Shows |
| JUPITER, a clinical trial suggesting rosuvastatin may lower the cardiovascular risk of healthy patients with elevated CRP, should not prompt universal statin use in older adults, according to a national poll directed at health professionals. Some 1,212 participants took part in the online poll conducted by medical news site MedPage Today LLC (http://www.MedPageToday.com).
11/26/2008
|
| Scientific Breakthrough In The Control Of Bad Cholesterol |
| A study performed by the team of Dr. Nabil G. Seidah, Director of the Biochemical Neuroendocrinology Research Unit at the IRCM, shows for the very first time that the degradation by PCSK9 of the LDLR receptor, which is responsible for removing the bad cholesterol (LDL-cholesterol) from the bloodstream, may be inhibited by a third protein, annexin A2. This major discovery co-authored by Gaétan Mayer, a postdoctoral fellow, Steve Poirier, a doctoral student, and Dr.
11/25/2008
|
| Key Elements Of Best Medical Treatment In Carotid Stenosis Patients Revealed - Encouraging Correlation Of Lowering LDL With Decreased Stroke Risk |
| Carotid artery disease is one of many atherosclerotic manifestations and it is associated with increased risk of stroke, myocardial infarction and death. Carotid surgery has been shown to reduce the risk of stroke both in symptomatic and asymptomatic patients although the benefit is by far larger in symptomatic patients with recent symptoms. But, as Dr.
11/24/2008
|
| Peripheral Fat Breakdown Undermined By Bad Cholesterol |
| The so called bad cholesterol (LDL) inhibits the breakdown of fat in cells of peripheral deposits, according to a study from the Swedish medical university Karolinska Institutet. The discovery reveals a novel function of LDL as a regulator of fat turnover besides its well-established detrimental effects in promoting atherosclerosis. The study, which is a collaboration of two research groups at Karolinska Institutet, is published in the open-access journal PLoS ONE.
11/20/2008
|
| Metabolex Announces Positive Results From Phase 2 Clinical Trial Of MBX-8025 |
| Metabolex, Inc., a biopharmaceutical company focused on the discovery and development of proprietary new medicines for the treatment of metabolic diseases, announced positive results from a Phase 2 clinical trial of MBX-8025. A summary of the results was presented at the World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy) on November 1, 2008. MBX-8025 is an oral drug candidate that is being evaluated for the treatment of dyslipidemia.
11/19/2008
|
| Soy Protein's Ability To Lower Cholesterol Confirmed, Possible Mechanism Of Action Described |
| Solae, a leader in soy protein innovation and technology, unveiled a new study today at the 8th International Symposium on the Role of Soy in Health Promotion and Chronic Disease Prevention and Treatment. A new meta-analysis confirms that soy protein consumption can lead to a meaningful and significant reduction in blood cholesterol levels.
11/17/2008
|
| Colesevelam HCl Lowered LDL Cholesterol In Pediatric Patients With Heterozygous Familial Hypercholesterolemia |
| Daiichi Sankyo, Inc. (DSI), announced today that results from the pivotal study supporting the use of colesevelam HCl in pediatric patients with heterozygous familial hypercholesterolemia (heFH), were presented for the first time at the American Heart Association's (AHA) Annual Scientific Sessions 2008.
11/17/2008
|
| The Influence Of Statin Medications On Prostate-specific Antigen Levels |
| UroToday.com - According to a report by Dr. Robert J. Hamilton and associates that appears in the November 5, 2008 issue of the Journal of the National Cancer Institute, statin use lowers PSA levels, and as a result may confound the detection of prostate cancer (CaP) in these patients. Statins are lipid-lowering agents in widespread use in the US. Several reports suggest that men on statins have a reduction in the risk of advanced CaP that ranges from 25% to 75%.
11/15/2008
|
| GP Survey Shows Concerns Over Tolerability Of Higher Dose Statins |
| According to the results of a new survey of 500 GPs across the UK, many GPs have concerns about the tolerability profile of higher doses of statins that are significant enough to affect their prescribing decisions.
11/14/2008
|
| Damage Inflicted During Cardiac Attacks More Widespread Than Previously Thought, MSU Researchers Find |
| Cholesterol crystals released in the bloodstream during a cardiac attack or stroke can damage artery linings much further away from the site of the attack, leaving survivors at greater risk than previously thought.
11/12/2008
|
| Health Risks For Large, Retired Athletes May Be Lowered By Staying Active |
| Study highlights: Retired NFL players have fewer heart disease risk factors overall, but higher cholesterol and glucose levels. Physical activity may have prevented the development of higher rates of diabetes or greater amounts of atherosclerosis. Since today's players are 50 percent larger than 25 years ago, further study is needed on whether current players are at greater risk for cardiovascular events or death, researchers said.
11/12/2008
|
| Statin Reduces Heart Attack, Stroke Rates In Patients With Normal Cholesterol But Elevated C-Reactive Protein |
| New data from the landmark ATHENA trial showed that dronedarone significantly reduced the incidence and total duration of hospital stays among patients with atrial fibrillation/atrial flutter (AF/AFL). This post-hoc analysis was presented at the 2008 American Heart Association Scientific Sessions in New Orleans, Louisiana. In this new analysis, dronedarone significantly reduced the total number of hospital days by 28 percent (p
11/12/2008
|
| Colesevelam HCl Lowered LDL Cholesterol In Pediatric Patients With Heterozygous Familial Hypercholesterolemia |
| Daiichi Sankyo, Inc. (DSI), announced that results from the pivotal study supporting the use of colesevelam HCl in pediatric patients with heterozygous familial hypercholesterolemia (heFH), were presented for the first time at the American Heart Association's (AHA) Annual Scientific Sessions 2008.
11/12/2008
|
