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PROHORMONES

 

Prohormones

A prohormone is a substance that is a precursor to a hormone, usually having minimal hormonal effect by itself. Examples of natural, human prohormones include proinsulin and pro-opiomelanocortin.

For peptide hormones, the conversion process from prohormone to hormone typically requires multiple processing enzymes.

Benefits of Prohormones

Prohormones have long been used by bodybuilders, athletes, and in anabolic steroids and other hormones with the expectation they would convert in the buyers' body to an active hormone.

A typical prohormone is marketed to the consumer as a precursor of an anabolic steroid such as testosterone, to boost the body’s available hormone supply. These precursors are intended to be converted to full, active hormones via an enzymatic process that occurs during metabolism, typically resulting in the addition of whichever atoms happen to be missing from the chemical structure of the compound.

The use of prohormones were used instead of synthetic steroids. Although the results were less dramatic than steroids, gains in muscular strength and growth of lean muscle mass were evident.

 


Studies

Their use remains quite controversial and side effects are not uncommon. To date most prohormone products have not been sufficiently studied to determine the term health effects of prolonged use.

 

Side Effects

The marketing of prohormones has been riddled with false representations and deceit. Most "prohormones" are questionably sold as dietary supplements to avoid the much tighter efficacy and safety requirements of the Food and Drug Administration (FDA) which apply to prescription hormones.

Prohormones are legally sold in most parts of the world and are classified in the United States by the FDA as dietary supplements because they consist of compounds that occur naturally in the human body. Following the Anabolic Steroid Control Act of 2004, prohormones and anabolic steroids are under the regulation of controlled substances.


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